PART TWO
Diagnostic Cytology
Fig. 7.36
(A)
Follicular cervicitis.
Vaginopancervical smear (Papanicolaou x OI). (B)
Follicular cervicitis,
LBGS. Diagnosis is difficult to make. Tingible
macrophages (arrow) and lymphocytes may be observed (Papanicolaou x HP).
Fig. 7.37 Follicular cervicitis.
Note the occurrence of a germinal follicle
and a capillary in this picture. Vaginopancervical smear (Papanicolaou x LP).
Hydropic or Ballooning Degeneration
This particular cellular change is often an effect of organelle
membrane damage caused by the virus. Certain degenerative
changes precede or accompany the development of inclusion
bodies and are often used in the diagnostic evaluation of
cellular changes (Fig. 7.38).
Necrosis
Viruses may cause coagulative necrosis and characteristic cyto-
plasmic changes. Most often, the cytoplasm becomes opaque
and thickened and loses its transparency and crispness. Nuclear
degenerative changes with karyolysis and karyorrhexis may
occur (Fig. 7.39). Only ghost forms of the infected cells may
remain.
Giant Cell Formation
Alterations in the membrane composition of the infected cells
contribute to the fusion of cells to produce syncytial and giant
forms. Sometimes nuclear inclusions may occur within the
multinucleated forms.
Fig. 7.38 Hydropic degeneration.
Vaginopancervical smear
(Papanicolaou x HP).
Fig. 7.39 Nuclear degeneration.
LBGS (Papanicolaou x HP).
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