Fig. 8.114 Cells from adenocarcinoma in a sheet-like arrangement. These
cells must be differentiated from cells derived from nonkeratinizing squamous
cell carcinoma. Differentiation is possible on the basis of cells in cluster-like
aggregates with eccentrically located nuclei. Cells from adenocarcinomas
usually have a slightly to moderately hyperchromatic, irregularly distributed
nuclear chromatin and large, very prominent nucleoli (Papanicolaou x OI).
Fig. 8.115 Keratinizing squamous cell cancer at low-power
magnification showing infiltration of stroma by large masses of tumor cells.
Keratin "pearl” formation is conspicuous (H&E x MP).
Fig. 8.116 Keratinizing squamous cell cancer. Characteristic increase
of cytoplasmic volume of centrally located cells in cell nests. Sometimes
cytoplasmic fibrillar structures can be found and densely eosinophilic
cytoplasmic condensates, creating a pseudo "pearl" structure (H&E x HP).
Fig. 8.117 Keratinizing squamous cell cancer. Binucleated tumor cell.
Nuclei have irregular shape and irregular distribution of coarsely granular
chromatin. Elongated cell with degenerated nucleus (Papanicolaou x OI).