Glandular Lesions of the Uterine Cervix
Fig. 9.17 In these examples of cells derived from well-differentiated mucinous endocervical adenocarcinoma ("adenoma malignum"), one can see
subtle nuclear pleomorphism of size and shape. Nuclear contour irregularities are noted (arrow in A). (B, C) Examples of pseudostratified strips of cells. These
strips contain more cytoplasm and show nucleus-to-cytoplasmic ratios much lower than are seen in the usual forms of adenocarcinoma and AIS.
(D) A 2-dimensional (flat) sheet of cells with prominent nucleoli (liquid-based preparation, Papanicolaou x HP).
Fig. 9.18 A case of the endometrioid variant of endocervical adenocarcinoma. Similar to its in situ counterpart illustrated in Fig. 9.13, this neoplasm
presents as densely packed groups of cells with high nucleus-to-cytoplasmic ratio. The nuclei are larger than the in situ lesion, but similar densely granular
chromatin structure is noted. Vague feathering can be seen at the margins of the groups. A bloody diathesis pattern is noted in the background (conventional
smear, Papanicolaou x HP).