13
Respiratory Tract
Table 13.9 Well-Differentiated Squamous Cell Carcinoma
Cytologic feature
Sputum
Bronchial wash
Bronchial brush
BAL
FNA
Single cells
+
+
+
+
+
Striking pleomorphism
of cell outline
+
+
+
+
+
Chromatin irregularly
dispersed and densely
hyperchromatic
+
+
+
+
+
Karyopyknosis
+
-
-
-
-
Nucleoli inconspicu-
ous or absent
+
-
-
-
-
Nucleoli obscured by
dense chromatin
+
-
-
-
-
Cytoplasm intensely
orangeophilic and
hyaline
+
+
+
Aberrant shapes
+
+
+
+
+
Ectoendoplasm, refrac-
tile ringing, and sharp
cytoplasmic outlines
+
Irregular cytoplasmic
thinning manifested
as caudate cells and
spindle cells
+
+
+
+
+
Keratinized squamous
ghosts
+
+
+
+
+
Keratin pearls
±
-
-
-
±
Small tissue fragments
-
-
+
-
+
Large irregular sheets
-
-
+
-
+
Inflammation and
necrosis
+
-
-
-
+
Herxheimer spirals
+
+
+
+
+
BAL = bronchoalveolar lavage; FNA=fine-needle aspiration.
Fig. 13.79 Moderately differentiated squamous cell carcinoma. Note
Fig. 13.80 Moderately differentiated squamous cell carcinoma.
the sharply defined cytoplasmic borders of many of the tumor cells and the
Bronchial brushing (Papanicolaou x OI).
large size of the nuclei. Sputum (Papanicolaou x OI).
337
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