Since the publication of the second edition of
in 1997 new trends in the practice of gynecologic and
non gynecologic cytology have emerged. Liquid based preparations
and HPV testing have been introduced in gynecologic cytology,
immunocytochemistry, clinical cytogenetics and molecular tech-
niques have seen expanded applications to non gynecologic
cytology, and fine needle aspiration under sonographic, computer
tomographic or fluoroscopic guidance for cytologic diagnosis
has become an indispensable component of the workup of body
lesions ,with more FNA's being performed by radiologists, and
endoscopists in close cooperation with cytologists.
The table of contents reflects additions and changes in topics
to provide detailed discussions of the significant advances
in the field. Examples include New concepts on molecular
basis of neoplasia (chapter 1), The role of genetics in cancer
development (chapter 2), Evaluation of the sample in smears
and liquid based preparations (chapter 5), FNA of Mediastinum
(chapter 26), FNA of Pediatric Tumors (chapter 29), Virtual
Microscopy (chapter 33), Automation of Cervical Cytology
(chapter 34), Molecular Techniques (chapter 36). Among the
unique features of this edition is the large number of more than
1700 color illustrations depicting the main diagnostic entities
with applications of adjunct techniques to cytopathology. New
contributors from institutions around the world (chapters 1, 2,
3, 6, 9, 10, 18, 21, 24, 25, 26, 28, 29, 33, 34, 35 & 36) have
joined the distinguished roster of authors not only to write new
chapters but also to rewrite them.
I would like to thank Dr David Wilbur for editing the chapters
in the FGT section of CC3E and for his valuable input. Thanks to
all contributors for their efforts and outstanding contributions.
Special thanks to Nani Clansey, Development Editor, for her
enormous help in the development of this work and William
R Schmitt, Editor, for his support and also to Rory MacDonald,
Project Manager, Stewart Larking, Designer and to Gillian
Richards, Illustration Manager in Elsevier Ltd.
In this third edition of
Comprehensive Cytopathology
we have
attempted, through an international group of experts to present
a state of the art work. Again we placed in a single comprehensive
book discussions on general cytology, diagnostic exfoliative
cytology of all body sites, entities and diagnostic challenges in
fine needle aspiration of various organs, effects of therapy on
cytologic specimens and special methodologies and technologies
in cytology. We hope that our attempt to incorporate advances
in the field while keeping emphasis on cytomorphology will be
valuable to all professionals interested in cytopathology.
Marluce Bibbo MD
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