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Thyroid
Fig. 23.8 Hürthle cell tumor. (A) Monomorphic cell population forming loosely cohesive sheets. There is marked anisonucleosis (Papanicolaou x MP).
(B) Cellular smear showing tissue fragments of Hürthle cells with no colloid in the background. Anisokaryosis is also evident (May-Grünwald-Giemsa x LP).
(C) Detail shows irregular-sized Hürthle cells with polygonal abundant granular cytoplasm and well-defined contour. Nuclei are slightly eccentric and contain
fine granular chromatin with a visible nucleolus. Anisokaryosis and binucleation are common findings. Colloid is absent (May-Grünwald-Giemsa x OI).
(D) Tissue fragment showing marked capillary vascularization (May-Grünwald-Giemsa x MP).
Fig. 23.9 Hürthle cell tumor. (A) Cytoplasmic vacuoles with reddish-purple inclusions in neoplastic Hürthle cells (May-Grünwald-Giemsa x OI). (B) Hürthle
cells with granular abundant cytoplasm and slightly excentric nuclei. Occasionally the nucleus may contain cytoplasmic inclusions (Papanicolou x OI).
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