6
The Bethesda System for Reporting cervical cytology
Table 6.1 The 2001 Bethesda System
SPECIMEN TYPE
Indicate conventional smear vs liquid-based preparation vs other
adeq uacy of the specimen
• Satisfactory for evaluation (describe presence or absence of endocervical/transformation zone component and any other
quality indicators, e.g., partially obscuring blood, inflammation)
• Unsatisfactory for evaluation .
.. (Specify reason)
- Specimen rejected/not processed (specify reason)
- Specimen processed and examined, but unsatisfactory for evaluation of epithelial abnormality because of (specify reason)
GENERAL CATEGoRizATioN (oPTioNAL)
• Negative for intraepithelial lesion or malignancy
• Other
• Epithelial cell abnormality: see Interpretation/Result (specify squamous
or
glandular as
appropriate)
iNTERPRETATioN/RESuLT
Negative for intraepithelial lesion or malignancy
(when there is no cellular evidence of neoplasia, state this in the General Categorization above and/or in the Interpretation/Result
section of the report— whether or not there are organisms or other non-neoplastic findings)
ORGANISMS
Trichom onas vaginalis
• Fungal organisms morphologically consistent with
Candida
spp.
• Shift in flora suggestive of bacterial vaginosis
• Bacteria morphologically consistent with
Actinom yces
spp.
• Cellular changes associated with herpes simplex virus
OTHER NON-NEOPLASTIC FINDINGS (OPTIONAL TO REPORT; LIST NOT INCLUSIVE)
• Reactive cellular changes associated with:
- Inflammation (includes typical repair)
- Radiation
- Intrauterine contraceptive device (IUD)
• Glandular cells status posthysterectomy
• Atrophy
Other
• Endometrial cells (in a woman > 40 years of age) (specify if "negative for squamous intraepithelial lesion")
Epithelial cell abnormalities
SQUAMOUS CELL
• Atypical squamous cells
- of undetermined significance (ASC-US)
- cannot exclude HSIL (ASC-H)
• Low-grade squamous intraepithelial lesion (LSIL) (encompassing: HPVt/mild dysplasia/CIN 1)
• High-grade squamous intraepithelial lesion (HSIL) (encompassing: moderate and severe dysplasia, CIS/CIN 2 and CIN 3)
- with features suspicious for invasion
• Squamous cell carcinoma
GLANDULAR CELL
• Atypical
- endocervical cells (NOS or specify in comments)
- endometrial cells (NOS or specify in comments)
- glandular cells (NOS or specify in comments)
• Atypical
- Endocervical cells, favor neoplastic
- Glandular cells, favor neoplastic
• Endocervical adenocarcinoma in situ
• Adenocarcinoma
- endocervical
- endometrial
- extrauterine adenocarcinoma
- not otherwise specified (NOS)
Other m alignant neoplasms (specify)
(continued)
79
previous page 81 ComprehensiveCytopathology 1104p 2008 read online next page 83 ComprehensiveCytopathology 1104p 2008 read online Home Toggle text on/off